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  • The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight-loss in addition to a reduced-calorie diet and exercise.

    Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you should err along the side of caution and allow FDA do its job and demand some investigation be done so your public is aware of the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies have been in business to earn money and that they would say everything to keep people on their own medications.

    Researchers found that participants taking this drug for a year, lost weight within one month and have kept the load off during the entire 56 weeks in the study. Contrave is really a combination from the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which can be made up of more than one active ingredient, which might make them more potent and safer.

    Combo-pilling may be the newest fad or in addition to this the newest ahead under scrutiny and so it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular will be the fact that at the time of right now there aren't any long term prescription diet pills that have been authorized by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be licensed by the FDA.

    Seizures can be a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug could also raise blood pressure level and pulse rate, and shouldn't be used in those with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

    The FDA also warned that Contrave can raise blood pressure and heartrate and must stop used in patients with uncontrolled high hypertension, as well as by you are not heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients towards the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

    "There were no signs and symptoms of depression or suicidal thoughts in trial participants," said Fujioka.

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